Chitosan Hydrogel Application Biomaterials Engineering Hydrogel Tissue Technology
Furane-alpha
2,5-FURANDICARBOXYLIC ACID
2,5-FURANDICARBOXYLIC ACID
.Efficacy of chitosan-based chewing gum on reducing salivary S. mutans counts and salivary pH : a randomized clinical trial.OBJECTIVE : To fix chitosan-based chewing gum role on reducing salivary S. mutans reckonings and salivary pH . MATERIALS AND method : The present double-blind randomized clinical trial with the trial enrollment routine of IRCT20190724044319N1 was conducted on 36 dental students .
The volunteers were , arbitrarily , divided into two groupings ( n = 18 ) admiting : G1 : interference grouping ( chitosan manducating gum ) and G2 : dominance group ( placebo chewing gum ) . Each participant was leaved eight mans of the chewing gum , and was asked to chew each gum bit for 5 min and this was recapitulated for eight metres . Their Saliva was amassed before and after chewing gums and the figure of S. mutans colonies and salivary pH were determined . Data were psychoanalyzed employing SPSS ( ver ) and independent pupil t test . p Value less than was set as substantial . solution : There was significant deviation between two groups for the bit of salivary S .
mutans colonies ( 3 * 105 in the intervention group equated to 13 * 105 in the command radical ) ( p < ) . The salivary pH valuation testified that salivary pH mean value in intervention group was not substantial in compared with ascendancy group ( p = ) the chitosan manduction gum led to an increase in salivary pH by 0 , which was statistically significant ( p = ) . finis : consequences of this discipline showed that chitosan masticating gum has a positive effect on the reducing of bits of salivary S. mutans Colonys but had no considerable effect on the addition of salivary pH.Nisin-loaded chitosan/sodium alginate microspheres enhance the antimicrobial efficaciousness of nisin against Staphylococcus aureus.AIMS : To uprise and assess nisin-loaded chitosan/sodium alginate ( CS/SA ) microspheres as an improved antimicrobial livery system pointing Staphylococcus aureus strains . METHODS AND RESULTS : The microspheres were readied using a modified water-in-oil emulsion cross-linking method , resulting in globular atoms sized 1-8 µm with a aerofoil charge of -7 ± 5 mV , reasserted by skiming electron microscopy ( SEM ) and Zetasizer psychoanalysis .
Encapsulation efficiency ( EE ) and loading capacity ( LC ) of nisin were 87 % ± 0 % and 1 % ± 0 % , severally . In vitro release subjects over 48 h indicated a controlled dismission design of nisin , described by the Korsmeyer-Peppas model , with gamy sacking rates at 37°C and alkalic pH . Antimicrobial assays showed an enhanced efficaciousness of nisin-loaded CS/SA microspheres compared to free nisin , with minimum repressive assiduousness values reduced by 50 % . Confocal laser scanning microscopy ( CLSM ) , SEM , and transmitting electron microscopy shewed substantial bacterial membrane term and cellular dislocation rushed by the microspheres This discipline highlights the potential of nisin-loaded CS/SA microspheres as an innovative antimicrobic delivery system with improved stability and antimicrobic efficaciousness against S. aureus , addressing restrictions associated with nisin practiced alone.Study of the Nanofibers fable Conditions from the commixture of Poly ( vinyl intoxicant ) and Chitosan by Electrospinning Method.Nanofiber lying is pulling capital attention from scientists and engineers due to its diligences in many fields of life .
In order to design a nanosized polymer-based drug saving system , we studied the conditions for the fabrication of electrospun nanofibers from poly ( vinyl intoxicant ) ( PVA ) and chitosan ( CS ) , which are long-familiar as biocompatible , biodegradable and non-toxic polymers that are wide used in the medical field . aspiring to originate nanofibers that can now direct pathologic cells for treatment , such as cancerous cadres , the ideal alternative would be a scheme that contains the highest CS content as well as high calibre roughages .