Ex Vivo Mucoadhesion Particles Mucosa Alg Peg Surface Modification Chitosan Nanoparticles Particle Stability Fluids Properties Nanocarrier Platform Mucosal Vaccine Delivery
FURAN-2,5-DICARBOXYLIC ACID
DEHYDROMUCIC ACID
Strain Ultrasound Elastography of Aneurysm Sac Content after Randomized Endoleak Embolization with Sclerosing vs. Non-sclerosing Chitosan-based Hydrogels in a Canine Model.PURPOSE: To compare the mechanical props of aneurysm content after endoleak embolization with a chitosan hydrogel (CH) with that with a chitosan hydrogel with sodium tetradecyl sulfate (CH-STS) using strain ultrasound elastography (SUE). textiles AND METHODS: Bilateral common iliac artery type Ia endoleaks were created in 9 dogs. Per animal, 1 endoleak was randomised to blinded embolization with CH, and the other, with CH-STS. Brightness-mode ultrasound, Doppler ultrasound, SUE radiofrequency ultrasound, and cyphered tomography were executed for up to 6 months until sacrifice.
Radiologic and histopathologic works were coregistered to identify 3 neighborhoods of interest: the embolic agent, intraluminal thrombus (ILT), and aneurysm sac. SUE divisions were doed by 2 dimed independent perceivers. The maximum axial strain (MAS) was the primary outcome. Statistical analysis was executed utilizing the Fisher exact test, multivariable linear mixed-issues modelings, and intraclass correlation coefficients (ICCs) Residual endoleaks were discovered in 7 of 9 (78%) and 4 of 9 (44%) aneurisms embolized with CH and CH-STS, respectively (P = ). CH-STS had a 66% lower MAS (P < ) than CH. The ILT had a 37% lower MAS (P = ) than CH and a 77% greater MAS (P = ) than CH-STS. There was no significant difference in ILT between discussions.
The aneurysm sacs embolized with CH-STS had a 29% lower MAS (P < ) than those embolized with CH. Residual endoleak was associated with a 53% greater MAS (P < ). The ICC for MAS was 0 (95% confidence interval: 0-0) between divisions CH-STS confers stiffer intraluminal holdings to embolized aneurisms. Persistent endoleaks are assorted with increased sac strain, an observation that may help guide management.An injectable supramolecular nanofiber-reenforced chitosan hydrogel with antibacterial and anti-inflammatory properties as potential carriers for drug delivery.The inherent weak mechanical strength of chitosan physical cross-linking hydrogels (CS hydrogels) limits their coverings in biomaterials puerarin (PUE) as a self-assembly active small molecule in herbal was infixed in CS hydrogels to fabricate CS/PUE(18) composite hydrogels with interpenetrating network structure. The result of rheological measurement demoed that storage modulus and loss modulus of CS/PUE(18) composite hydrogels were bettered by three ordinations of magnitude, showing that the introduction of PUE significantly reenforced CS hydrogels.
The solvents of SEM and BET measurement evidenced that macromolecular concatenations of CS intertwined with nanofibers of PUE, which doed the network structure of CS/PUE(18) composite hydrogels to become denser. XRD shapes and FT-IR spectra swaned that the amino groups in CS worked hydrogen bonding with the hydroxyl groups in PUE. Degradation and swelling experimentations pointed that CS/PUE(18) composite hydrogels have pH sensitivity CS/PUE(18) composite hydrogels presented multi-functionality including injectability, thixotropy, cytocompatibility, antibacterial and anti-inflammatory attributes. The release behavior of berberine chloride hydrate (BCH) and PUE from the resultant CS/PUE(18) composite hydrogels have pH dependence. These results unwraped that injectable CS/PUE(18) composite hydrogels with dual antibacterial and anti-inflammatory props could be potential delivery fomites for sustained and controlled release.Adsorption Behavior of Methylene Blue Dye by Novel CrossLinked O-CM-Chitosan Hydrogel in Aqueous Solution: Kinetics, Isotherm and Thermodynamics.The chemical cross-linking of carboxymethyl chitosan (O-CM-chitosan), as a method for its modification, was executed using trimellitic anhydride isothiocyanate to obtain novel cross-related O-CM-chitosan hydrogel.
Its structure was leavened practicing FTIR, XRD and SEM.