Gel Characterization Vitro Release Vitro Permeation Vivo Activity
Organic raw materials
RARECHEM AL BO 0910
The results expressed that the formulated CME-KCS gel had an orange-yellow and gel-like appearance. The particle size and zeta potential of the CME-KCS gel were 186 ± 0 nm and 9 ± 0 mV, respectively. The CME-KCS gel readed desirable viscoelasticity, spreadability, bioadhesion and operated drug release, which was suitable for topical application. The in vitro skin permeation and retention study rendered that the CME-KCS gel had better in vitro skin penetration than the Cur solution and accomplished maximum skin drug retention (3 ± 0 μg/cm(2)). In vivo experimental effects corroborated that the CME-KCS gel was more effective than curcumin-diluted microemulsion (Cur-ME) in analgesic and anti-inflammatory activities. In addition, the CME-KCS gel did not cause any erythema or edema finded on a mice skin irritation test.
These findings designated that the trained CME-KCS gel could improve the skin penetration and retention of Cur and could become a promising formulation for topical delivery to treat local diseases.Characterisation, slow-release, and antibacterial dimensions of carboxymethyl chitosan/inulin hydrogel film stretched with novel antilisterial durancin GL.This paper reports the development of a hydrogel film with antibacterial activity and commanded release characteristics. Carboxymethyl chitosan (CMCS) is engrafted onto durancin GL and inulin via a mediated reaction between N-hydroxysuccinimide and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride. Rheology tests, Fourier transform infrared (FTIR) spectroscopy, X-ray photoelectron spectroscopy, and lap shear tests reasserted the formation of a stable chemical cross-linking and excellent adhesion hydrogel with 4 % CMCS and 8 % inulin. The CMCS/inulin hydrogel film charged with durancin GL appears transparent and uniform. FTIR spectroscopy answers reveal the interaction mode among CMCS, inulin, durancin GL, and the hydrogel film structure.
Cross-connecting bettered thermal stability and water-vapour barrier performance. The hydrophobicity of CMCS/inulin @Durancin GL increased under a durancin GL concentration of 0 g/30 mL, and the release of active cores is protracted. In-vitro antibacterial capacity and salmon preservation experimentations show that the addition of durancin GL enhanced the antibacterial activity of the hydrogel film CMCS/inulin@Durancin GL hydrogel cinemas can be used as fresh-keeping packaging cloths in practical coverings.Biomimetic Hydroxyapatite Crystals Growth on Phosphorylated Chitosan Films by In Vitro Mineralization Used as Dental Substitute Materials.Chitosan (CS) cinemas exhibit great potential as a substrate for the in vitro mineralization process. In this study, to mimic the formation of nanohydroxyapatite (HAP) as natural tissue, CS films caked with a porous calcium phosphate were enquired using scanning electron microscopy (SEM), Energy dispersive X-ray spectroscopy (EDX), Fourier translates infrared spectroscopy (FTIR), X-ray diffractometry (XRD) and X-ray photoelectron spectroscopy (XPS). Calcium phosphate caking wedged on phosphorylated differentials of CS was incured by a process based on phosphorylation, Ca(OH)(2) treatment and artificial saliva solution (ASS) immersion.
The phosphorylated CS movies (PCS) were obtained by partial hydrolysis of the PO(4) functionalities. It was demonstrated that this precursor phase could induce the growth and the nucleation of the porous calcium phosphate surfacing when swallowed in ASS orientated crystallizations and qualitative control of calcium phosphate phases on CS matrices are prevailed in a biomimetic mode in vitro antimicrobial activity of PCS was judged against three mintages of oral bacteriums and fungi. It revealed an increase in antimicrobial activity with minimum inhibition concentration (MIC) values of 0% (Candida albicans), 0% (Staphylococcus aureus) and 0% (Escherichia coli) which shews their possible use as dental substitute materials.Development of Chitosan Green Composites rewarded with Hemp Fibers: Study of Mechanical and Barrier Properties for Packaging Application.The use of bioresourced packaging materials is an interesting solution for ecological offsprings.