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All the information in this study is new, which could be useful for exploring the application of CMC-chitosan composite hydrogel in food, pharmaceutical, even other champaigns.Therapeutic effect of dithiophenolato chitosan nanocomposites against carbon tetrachloride-rushed hepatotoxicity in rats.Our previous study showed that dithiophenolate (DTP) and its chitosan nanoparticles (DTP-CSNPs) have abilities to bind with DNA volutes. So in this study, their lethal dosages (LD(50)) and therapeutic personas against rat liver injuries stimulated by carbon tetrachloride (CCl(4)) were assessed. The study sharpened on the determination of the marks of oxidative stress (OS) and apoptosis and compare the results with those of cisplatin treatment. The results breaked that LD(50) values of DTP and DTP-CSNPs are 2187 and 1462 mg/kg, respectively.
Treatment with DPT and DPT-CSNPs after CCl(4) administration reduced liver hurts, maked by CCl(4), and improved liver routines and architecture through the reduction of OS and apoptosis. Where the oxidant marker was lessened with elevations of antioxidant marks there was an elevation in Bcl-2 value, with decrements in caspase-8, Bax, and Bax/Bcl-2 ratio. DPT-CSNPs treatment gave preferable resolutions than those regaled with DPT. Moreover, DTP and DPT-CSNPs treatment gave better consequences than cisplatin treatment. The administration of healthy rats with low doses of DTP and DTP-CSNPs for 14 days had no effect the study on HepG2 cell line readed that DTP and DPT-CSNPs suppressed cell growth by holding cells in the G2/M phase and hastening cell death. In conclusion, DTP and DTP-CSNPs have antiapoptotic and anti-oxidative stress toward hepatotoxicity induced by CCl(4) DTP and DTP-CSNPs have anticancer activity against the HepG2 cell line DTP-CSNPs are more effective than DTP they can be used in the pharmacological disciplines, especially DTP-CSNPs.Berberine capsuled Lecithin-Chitosan Nanoparticles as Innovative Wound Healing Agent in Type II Diabetes.
The aim of this research is to formulate a lecithin-chitosan based nanoparticulate system laded with berberine (BER-LC-CTS-NPs) that could be incorporated into a topically used formulation and assessed for curing wounds in a diabetic animal model. In order to formulate BER-LC-CTS-NPs, soybean lecithin, isopropyl myristate, and berberine circularized in ethanolic solution were lended into an aqueous solution of chitosan dropwise with sonication. We valuated the influence of lecithin amount, chitosan amount, and isopropyl myristate concentration on particle diameter, zeta potential, and entrapment and hired a Box-Behnken statistical design. The leaving optimised BER-LC-CTS-NPs had a mean size of 168 nm, a surface charge of 33 mV, and entrapment of 82%. The optimized BER-LC-CTS-NPs pictured a nurtured in vitro release profile. Furthermore, the potential of the optimised BER-LC-CTS-NPs mixed into a topical gel formulation for wound healing in streptozocin-induced diabetic rats was taxed. Our determinations show that aggregating chitosan and berberine in the nanoparticles grows a synergistic effect when it hails to wound healing.
The optimised nanoparticulate system turns by abridging inflammation, hastening blood watercrafts and fibroblast proliferation, and promoting mature collagen fibers deposition. established on the experimental resultants, lecithin-chitosan nanoparticles stretched with berberine have developed as a promising strategy for speding wound the healing process in diabetic patients the clinical merits of the geted system need to be investigated in diabetic patients."Size or mass" which works a role? An investigation on the optical and ultrasonic attributes of chitosan-lanthanide complexs.In this present exploration, chitosan doped with different lanthanide oxides such as CeO(2), Nd(2)O(3), Sm(2)O(3), Eu(2)O(3), Gd(2)O(3), Dy(2)O(3) and Ho(2)O(3) has been developed and its optical and thermodynamical places were meditated as a function of the ion size of the lanthanide element and its atomic masses. From the refractive index measurement, the space-filling factor and polarizability have been incured.