The CS-AgNPs Microspheres Demonstrate Promising Antimicrobial And Biocompatible Factors For Medical Field Diligences
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Tumor microenvironment bottoming chitosan nanoparticles for elimination of cancer relapse and minimal residual disease.Chitosan and its derivatives are among biomaterials with numerous medical coverings, especially in cancer. Chitosan is amenable to constituting innumerable conformations such as micelles, niosomes, hydrogels, nanoparticles, and scaffolds, among others. Chitosan differentials can also bring unprecedented potential to cross numerous biological barriers. blended with other biomaterials, hybrid and multitasking chitosan-established systems can be seed for many coverings. These include controlled drug release, directed drug delivery, post-surgery implants (immunovaccines), theranostics, biosensing of tumor-infered circulating textiles, multimodal schemes, and combination therapy platforms with the potential to eliminate bulk neoplasms as well as lingering tumor cellphones to treat minimal residual disease (MRD) and recurrent cancer.
We first introduce different formattings, derivatives, and holdings of chitosan given the roadblocks to therapeutic efficacy in solid tumors, we review advanced conceptualizations of chitosan modules as efficient drug delivery systems to overcome tumor heterogeneity, multi-drug resistance, MRD, and metastasis we discuss chitosan NPs for clinical translation and treatment of recurrent cancer and their future perspective.Development and characterization of chitosan/bacterial cellulose/pullulan bilayer film with sustained release curcumin.A natural biopolymer bilayer film established on chitosan and bacterial cellulose with a protective layer of pullulan was prepared by a two-step solution spewing method. Curcumin was integrated as an active antioxidant and antibacterial agent into the inner layer. The flicks with different curcumin tightnessses were systematically characterized. Fourier transform infrared spectroscopy and X-ray diffraction analyses registered high compatibility between curcumin and the polysaccharide matrix through intermolecular interactions, which was affirmed by heightened mechanical and barrier places. The curcumin incorporation meliorated the thermal stability by >35 %, along with lower visible and ultraviolet light transmittance (< 8 %) and water solubility (< 25 %).
The film had both antibacterial and antioxidant dimensions, and the keeped release of curcumin was largest (> 58 %) in the fatty food simulant living for over 155 h. The results suggested that the film holding 0 % curcumin had ideal physical and functional properties, intimating its potential as a novel packaging material for the preservation of high-fat food.Chitosan engrafted tetracarboxylic functionalized magnetic nanoparticles for removal of Pb(II) from an aqueous environment.In this study, the chitosan-ingrafted tetracarboxylic functionalized magnetic nanoparticle (Fe(3)O(4)@TCA@CS) was synthesized via in situ co-precipitation process and amidation reaction to improve efficiency of adsorption process and obtain cost-effective adsorbents for removal of toxic Pb(II) metal from aqueous environment. The Fe(3)O(4)@TCA@CS nanocomposite was analyzed by FTIR, TEM-EDX, TGA, XRD, BET, and Zeta potential. The performance of Fe(3)O(4)@TCA@CS for Pb(II) ions adsorption was accomplished as a function of pH, dose, contact time, initial Pb(II) concentration, and temperature. The influence of coexisting ions such as Na(+), Ca(2+), Mg(2+), and Cd(2+)on removal efficiency of Pb(II) was also inquired.
The terminations revealed that the coexisting ions had little influence on Pb(II) removal efficiency. The pseudo-first-order and Freundlich manakins were better to describe the adsorption of Pb(II) onto Fe(3)O(4)@TCA@CS and the maximum adsorption capacity of Pb(II) was 204 mg/g at pH:5; adsorbent dose: 0 g; and temperature: 298 K. Thermodynamic sketchs revealed that the Pb(II) adsorption onto Fe(3)O(4)@TCA@CS was an exothermic process. In conclusion, the study offers a new, simple, low-cost, and effective chitosan-based magnetic nanocomposite as a promising adsorbent with excellent adsorption capacity, magnetic separation, and reusability for Pb(II) removal from an aqueous environment.Pickering emulsions with chitosan and macroalgal polyphenols braced by layer-by-layer electrostatic deposition.